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KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

The first step of RAF activation involves binding to active RAS, resulting in the recruitment of RAF to the plasma membrane. To understand the molecular details of RAS-RAF interaction, we present crystal structures of wild-type and oncogenic mutants of KRAS complexed with the RAS-binding domain (RBD...

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הוצא לאור ב:	Nat Commun
Main Authors:	Tran, Timothy H., Chan, Albert H., Young, Lucy C., Bindu, Lakshman, Neale, Chris, Messing, Simon, Dharmaiah, Srisathiyanarayanan, Taylor, Troy, Denson, John-Paul, Esposito, Dominic, Nissley, Dwight V., Stephen, Andrew G., McCormick, Frank, Simanshu, Dhirendra K.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Nature Publishing Group UK 2021
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7895934/ https://ncbi.nlm.nih.gov/pubmed/33608534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21422-x
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KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

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