KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

The first step of RAF activation involves binding to active RAS, resulting in the recruitment of RAF to the plasma membrane. To understand the molecular details of RAS-RAF interaction, we present crystal structures of wild-type and oncogenic mutants of KRAS complexed with the RAS-binding domain (RBD...

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Publicado en:Nat Commun
Autores principales: Tran, Timothy H., Chan, Albert H., Young, Lucy C., Bindu, Lakshman, Neale, Chris, Messing, Simon, Dharmaiah, Srisathiyanarayanan, Taylor, Troy, Denson, John-Paul, Esposito, Dominic, Nissley, Dwight V., Stephen, Andrew G., McCormick, Frank, Simanshu, Dhirendra K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895934/
https://ncbi.nlm.nih.gov/pubmed/33608534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21422-x
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