Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ

Farnesylation and carboxymethylation of KRAS4b (Kirsten rat sarcoma isoform 4b) are essential for its interaction with the plasma membrane where KRAS-mediated signaling events occur. Phosphodiesterase-δ (PDEδ) binds to KRAS4b and plays an important role in targeting it to cellular membranes. We solv...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Dharmaiah, Srisathiyanarayanan, Bindu, Lakshman, Tran, Timothy H., Gillette, William K., Frank, Peter H., Ghirlando, Rodolfo, Nissley, Dwight V., Esposito, Dominic, McCormick, Frank, Stephen, Andrew G., Simanshu, Dhirendra K.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098621/
https://ncbi.nlm.nih.gov/pubmed/27791178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615316113
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars