Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ

Farnesylation and carboxymethylation of KRAS4b (Kirsten rat sarcoma isoform 4b) are essential for its interaction with the plasma membrane where KRAS-mediated signaling events occur. Phosphodiesterase-δ (PDEδ) binds to KRAS4b and plays an important role in targeting it to cellular membranes. We solv...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dharmaiah, Srisathiyanarayanan, Bindu, Lakshman, Tran, Timothy H., Gillette, William K., Frank, Peter H., Ghirlando, Rodolfo, Nissley, Dwight V., Esposito, Dominic, McCormick, Frank, Stephen, Andrew G., Simanshu, Dhirendra K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098621/
https://ncbi.nlm.nih.gov/pubmed/27791178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615316113
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