Structures of N-terminally processed KRAS provide insight into the role of N-acetylation

Although post-translational modification of the C-terminus of RAS has been studied extensively, little is known about N-terminal processing. Mass spectrometric characterization of KRAS expressed in mammalian cells showed cleavage of the initiator methionine (iMet) and N-acetylation of the nascent N-...

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Pubblicato in:Sci Rep
Autori principali: Dharmaiah, Srisathiyanarayanan, Tran, Timothy H., Messing, Simon, Agamasu, Constance, Gillette, William K., Yan, Wupeng, Waybright, Timothy, Alexander, Patrick, Esposito, Dominic, Nissley, Dwight V., McCormick, Frank, Stephen, Andrew G., Simanshu, Dhirendra K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642148/
https://ncbi.nlm.nih.gov/pubmed/31324887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46846-w
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