KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis

KRAS mutations occur in ∼35% of colorectal cancers and promote tumor growth by constitutively activating the mitogen-activated protein kinase (MAPK) pathway. KRAS mutations at codons 12, 13, or 61 are thought to prevent GAP protein-stimulated GTP hydrolysis and render KRAS-mutated colorectal cancers...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Rabara, Dana, Tran, Timothy H., Dharmaiah, Srisathiyanarayanan, Stephens, Robert M., McCormick, Frank, Simanshu, Dhirendra K., Holderfield, Matthew
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825300/
https://ncbi.nlm.nih.gov/pubmed/31611389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908353116
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