Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

K-RAS4B (Kirsten rat sarcoma viral oncogene homolog 4B) is a prenylated, membrane-associated GTPase protein that is a critical switch for the propagation of growth factor signaling pathways to diverse effector proteins, including rapidly accelerated fibrosarcoma (RAF) kinases and RAS-related protein...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mazhab-Jafari, Mohammad T., Marshall, Christopher B., Smith, Matthew J., Gasmi-Seabrook, Geneviève M. C., Stathopulos, Peter B., Inagaki, Fuyuhiko, Kay, Lewis E., Neel, Benjamin G., Ikura, Mitsuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450377/
https://ncbi.nlm.nih.gov/pubmed/25941399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419895112
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