Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane

Membrane anchoring of farnesylated KRAS is critical for activation of RAF kinases, yet our understanding of how these proteins interact on the membrane is limited to isolated domains. The RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF engage KRAS and the plasma membrane, unleashing t...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Fang, Zhenhao, Lee, Ki-Young, Huo, Ku-Geng, Gasmi-Seabrook, Geneviève, Zheng, Le, Moghal, Nadeem, Tsao, Ming-Sound, Ikura, Mitsuhiko, Marshall, Christopher B.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275734/
https://ncbi.nlm.nih.gov/pubmed/32414921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914076117
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