Antitumor efficacy of XPO1 inhibitor Selinexor in KRAS-mutant lung adenocarcinoma patient-derived xenografts

Gain-of-function Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations occur in 25% of lung adenocarcinomas, and these tumors are challenging to treat. Some preclinical work, largely based on cell lines, suggested KRAS(mut) lung cancers are especially dependent on the nuclear export protein ex...

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Bibliografiske detaljer
Udgivet i:Transl Oncol
Main Authors: Rosen, Joshua C., Weiss, Jessica, Pham, Nhu-An, Li, Quan, Martins-Filho, Sebastiao N., Wang, Yuhui, Tsao, Ming-Sound, Moghal, Nadeem
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press 2021
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313753/
https://ncbi.nlm.nih.gov/pubmed/34284202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2021.101179
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