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Antitumor efficacy of XPO1 inhibitor Selinexor in KRAS-mutant lung adenocarcinoma patient-derived xenografts
Gain-of-function Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations occur in 25% of lung adenocarcinomas, and these tumors are challenging to treat. Some preclinical work, largely based on cell lines, suggested KRAS(mut) lung cancers are especially dependent on the nuclear export protein ex...
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| Publicado no: | Transl Oncol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Neoplasia Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8313753/ https://ncbi.nlm.nih.gov/pubmed/34284202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2021.101179 |
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