XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies

Treatment options for high grade urothelial cancers are limited and have remained largely unchanged for several decades. Selinexor (KPT-330), a first in class small molecule that inhibits the nuclear export protein XPO1, has shown efficacy as a single agent treatment for numerous different malignanc...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Baek, Han Bit, Lombard, Alan P., Libertini, Stephen J., Fernandez-Rubio, Aleida, Vinall, Ruth, Gandour-Edwards, Regina, Nakagawa, Rachel, Vidallo, Kathleen, Nishida, Kristine, Siddiqui, Salma, Wettersten, Hiromi, Landesman, Yosef, Weiss, Robert H., Ghosh, Paramita M., Mudryj, Maria
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2018
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6195388/
https://ncbi.nlm.nih.gov/pubmed/30349650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26179
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