The p14ARF tumor suppressor restrains androgen receptor activity and prevents apoptosis in prostate cancer cells

Prostate cancer (PCa) is characterized by a unique dependence on optimal androgen receptor (AR) activity where physiological androgen concentrations induce proliferation but castrate and supraphysiological levels suppress growth. This feature has been exploited in bipolar androgen therapy (BAT) for...

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Pubblicato in:Cancer Lett
Autori principali: Siddiqui, Salma, Libertini, Stephen J., Lucas, Christopher A., Lombard, Alan P., Baek, Han Bit, Nakagawa, Rachel M., Nishida, Kristine S., Steele, Thomas M., Melgoza, Frank U., Borowsky, Alexander D., Durbin-Johnson, Blythe P., Qi, LiHong, Ghosh, Paramita M., Mudryj, Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034238/
https://ncbi.nlm.nih.gov/pubmed/32330514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2020.03.030
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