XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies

Treatment options for high grade urothelial cancers are limited and have remained largely unchanged for several decades. Selinexor (KPT-330), a first in class small molecule that inhibits the nuclear export protein XPO1, has shown efficacy as a single agent treatment for numerous different malignanc...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Baek, Han Bit, Lombard, Alan P., Libertini, Stephen J., Fernandez-Rubio, Aleida, Vinall, Ruth, Gandour-Edwards, Regina, Nakagawa, Rachel, Vidallo, Kathleen, Nishida, Kristine, Siddiqui, Salma, Wettersten, Hiromi, Landesman, Yosef, Weiss, Robert H., Ghosh, Paramita M., Mudryj, Maria
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2018
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6195388/
https://ncbi.nlm.nih.gov/pubmed/30349650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26179
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