XPO1 inhibition with selinexor synergizes with proteasome inhibition in neuroblastoma by targeting nuclear export of IkB

Across many cancer types in adults, upregulation of the nuclear-to-cytoplasmic transport protein Exportin-1 (XPO1) correlates with poor outcome and responsiveness to selinexor, an FDA-approved XPO1 inhibitor. Similar data are emerging in childhood cancers, for which selinexor is being evaluated in e...

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Vydáno v:Transl Oncol
Hlavní autoři: Galinski, Basia, Luxemburg, Marcus, Landesman, Yosef, Pawel, Bruce, Johnson, Katherine J., Master, Stephen R., Freeman, Kevin W., Loeb, David M., Hébert, Jean M., Weiser, Daniel A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press 2021
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131731/
https://ncbi.nlm.nih.gov/pubmed/33975179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2021.101114
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