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NMR-based functional profiling of RASopathies and oncogenic RAS mutations
Defects in the RAS small G protein or its associated network of regulatory proteins that disrupt GTPase cycling are a major cause of cancer and developmental RASopathy disorders. Lack of robust functional assays has been a major hurdle in RAS pathway-targeted drug development. We used NMR to obtain...
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| Główni autorzy: | , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2013
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3607025/ https://ncbi.nlm.nih.gov/pubmed/23487764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218173110 |
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