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Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
Aberrant signaling by oncogenic mutant rat sarcoma (Ras) proteins occurs in ∼15% of all human tumors, yet direct inhibition of Ras by small molecules has remained elusive. Recently, several small-molecule ligands have been discovered that directly bind Ras and inhibit its function by interfering wit...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690838/ https://ncbi.nlm.nih.gov/pubmed/23737504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300016110 |
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