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NMR-based functional profiling of RASopathies and oncogenic RAS mutations

Defects in the RAS small G protein or its associated network of regulatory proteins that disrupt GTPase cycling are a major cause of cancer and developmental RASopathy disorders. Lack of robust functional assays has been a major hurdle in RAS pathway-targeted drug development. We used NMR to obtain...

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Библиографические подробности
Главные авторы: Smith, Matthew J., Neel, Benjamin G., Ikura, Mitsuhiko
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607025/
https://ncbi.nlm.nih.gov/pubmed/23487764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218173110
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