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Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer
Activation of Crtc1 (also known as Mect1/Torc1) by a t(11;19) chromosomal rearrangement underlies the etiology of malignant salivary gland tumors. Since LKB1 is a target for mutational inactivation in lung cancer and was recently shown to regulate hepatic Crtc2/CREB transcriptional activity in mice,...
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| Publicat a: | Oncogene |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7227613/ https://ncbi.nlm.nih.gov/pubmed/20010869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.453 |
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