Role of LKB1-CRTC1 on Glycosylated COX-2 and Response to COX-2 Inhibition in Lung Cancer

BACKGROUND: Cyclooxygenase-2 (COX-2) directs the synthesis of prostaglandins including PGE-2 linking inflammation with mitogenic signaling. COX-2 is also an anticancer target, however, treatment strategies have been limited by unreliable expression assays and by inconsistent tumor responses to COX-2...

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Publicado en:J Natl Cancer Inst
Autores principales: Cao, Chunxia, Gao, Ruli, Zhang, Min, Amelio, Antonio L., Fallahi, Mohammad, Chen, Zirong, Gu, Yumei, Hu, Chengbin, Welsh, Eric A., Engel, Brienne E., Haura, Eric B., Cress, W. Douglas, Wu, Lizi, Zajac-Kaye, Maria, Kaye, Frederic J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271078/
https://ncbi.nlm.nih.gov/pubmed/25465874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/dju358
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