cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth

The LKB1 tumor suppressor gene is frequently mutated and inactivated in non–small cell lung cancer (NSCLC). Loss of LKB1 promotes cancer progression and influences therapeutic responses in preclinical studies; however, specific targeted therapies for lung cancer with LKB1 inactivation are currently...

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Vydáno v:J Clin Invest
Hlavní autoři: Chen, Zirong, Li, Jian-Liang, Lin, Shuibin, Cao, Chunxia, Gimbrone, Nicholas T., Yang, Rongqiang, Fu, Dongtao A., Carper, Miranda B., Haura, Eric B., Schabath, Matthew B., Lu, Jianrong, Amelio, Antonio L., Cress, W. Douglas, Kaye, Frederic J., Wu, Lizi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887185/
https://ncbi.nlm.nih.gov/pubmed/27140397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85250
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