cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth

The LKB1 tumor suppressor gene is frequently mutated and inactivated in non–small cell lung cancer (NSCLC). Loss of LKB1 promotes cancer progression and influences therapeutic responses in preclinical studies; however, specific targeted therapies for lung cancer with LKB1 inactivation are currently...

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Gepubliceerd in:J Clin Invest
Hoofdauteurs: Chen, Zirong, Li, Jian-Liang, Lin, Shuibin, Cao, Chunxia, Gimbrone, Nicholas T., Yang, Rongqiang, Fu, Dongtao A., Carper, Miranda B., Haura, Eric B., Schabath, Matthew B., Lu, Jianrong, Amelio, Antonio L., Cress, W. Douglas, Kaye, Frederic J., Wu, Lizi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887185/
https://ncbi.nlm.nih.gov/pubmed/27140397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85250
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