Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation

Lung cancer with loss-of-function of the LKB1 tumor suppressor is a common aggressive subgroup with no effective therapies. LKB1-deficiency induces constitutive activation of cAMP/CREB-mediated transcription by a family of three CREB-regulated transcription coactivators (CRTC1-3). However, the signi...

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Udgivet i:eLife
Main Authors: Zhou, Xin, Li, Jennifer W, Chen, Zirong, Ni, Wei, Li, Xuehui, Yang, Rongqiang, Shen, Huangxuan, Liu, Jian, DeMayo, Francesco J, Lu, Jianrong, Kaye, Frederic J, Wu, Lizi
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2021
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8238510/
https://ncbi.nlm.nih.gov/pubmed/34142658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66095
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