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Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation
Lung cancer with loss-of-function of the LKB1 tumor suppressor is a common aggressive subgroup with no effective therapies. LKB1-deficiency induces constitutive activation of cAMP/CREB-mediated transcription by a family of three CREB-regulated transcription coactivators (CRTC1-3). However, the signi...
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| Wydane w: | eLife |
|---|---|
| Główni autorzy: | , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
eLife Sciences Publications, Ltd
2021
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8238510/ https://ncbi.nlm.nih.gov/pubmed/34142658 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66095 |
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