Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer

Activation of Crtc1 (also known as Mect1/Torc1) by a t(11;19) chromosomal rearrangement underlies the etiology of malignant salivary gland tumors. Since LKB1 is a target for mutational inactivation in lung cancer and was recently shown to regulate hepatic Crtc2/CREB transcriptional activity in mice,...

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Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: Komiya, Takefumi, Coxon, Amy, Park, Yoonsoo, Chen, Wei-dong, Zajac-Kaye, Maria, Meltzer, Paul, Karpova, Tatiana, Kaye, Frederic J.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7227613/
https://ncbi.nlm.nih.gov/pubmed/20010869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.453
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