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A sensitive NanoString-based assay to score STK11 (LKB1) pathway disruption in lung adenocarcinoma

INTRODUCTION: Serine/threonine kinase 11 (STK11), better known as LKB1, is a tumor-suppressor commonly mutated in lung adenocarcinoma (LUAD). Previous work has shown that mutational inactivation of the STK11 pathway may serve as a predictive biomarker for cancer treatments including phenformin and C...

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發表在:J Thorac Oncol
Main Authors: Chen, Lu, Engel, Brienne E., Welsh, Eric A., Yoder, Sean J., Brantley, Stephen G., Chen, Dung-Tsa, Beg, Amer A., Cao, Chunxia, Kaye, Frederic J., Haura, Eric B., Schabath, Matthew B., Cress, W. Douglas
格式: Artigo
語言:Inglês
出版: 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877210/
https://ncbi.nlm.nih.gov/pubmed/26917230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2016.02.009
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