A sensitive NanoString-based assay to score STK11 (LKB1) pathway disruption in lung adenocarcinoma

INTRODUCTION: Serine/threonine kinase 11 (STK11), better known as LKB1, is a tumor-suppressor commonly mutated in lung adenocarcinoma (LUAD). Previous work has shown that mutational inactivation of the STK11 pathway may serve as a predictive biomarker for cancer treatments including phenformin and C...

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Publicado en:J Thorac Oncol
Autores principales: Chen, Lu, Engel, Brienne E., Welsh, Eric A., Yoder, Sean J., Brantley, Stephen G., Chen, Dung-Tsa, Beg, Amer A., Cao, Chunxia, Kaye, Frederic J., Haura, Eric B., Schabath, Matthew B., Cress, W. Douglas
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877210/
https://ncbi.nlm.nih.gov/pubmed/26917230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2016.02.009
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