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Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism
Isocitrate dehydrogenase (IDH) mutation is a common genetic abnormality in human malignancies characterized by remarkable metabolic reprogramming. Our present study demonstrated that IDH1-mutated cells showed elevated levels of reactive oxygen species and higher demands on Nrf2-guided glutathione de...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7211987/ https://ncbi.nlm.nih.gov/pubmed/32312817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913633117 |
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