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EXTH-03. TRIPTOLIDE, A NOVEL THERAPEUTIC AGENT FOR IDH1-MUTATED GLIOMA

BACKGROUND: Isocitrate dehydrogenase (IDH1/2) mutations are common genetic abnormalities in human malignancies, which result in neomorphic enzyme activity that catalyzes 2-hydroxyglutarate (2-HG) production. While IDH mutations are recognized as critical cancer-associated genetic changes, the therap...

詳細記述

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書誌詳細
出版年:Neuro Oncol
主要な著者: Yu, Di, Liu, Yang, Xu, Guowang, Yang, Chunzhang
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847942/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.337
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