Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism

Isocitrate dehydrogenase (IDH) mutation is a common genetic abnormality in human malignancies characterized by remarkable metabolic reprogramming. Our present study demonstrated that IDH1-mutated cells showed elevated levels of reactive oxygen species and higher demands on Nrf2-guided glutathione de...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Yu, Di, Liu, Yang, Zhou, Yiqiang, Ruiz-Rodado, Victor, Larion, Mioara, Xu, Guowang, Yang, Chunzhang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2020
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7211987/
https://ncbi.nlm.nih.gov/pubmed/32312817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913633117
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