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Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism
Isocitrate dehydrogenase (IDH) mutation is a common genetic abnormality in human malignancies characterized by remarkable metabolic reprogramming. Our present study demonstrated that IDH1-mutated cells showed elevated levels of reactive oxygen species and higher demands on Nrf2-guided glutathione de...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7211987/ https://ncbi.nlm.nih.gov/pubmed/32312817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913633117 |
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