Targeting IDH1-Mutated Malignancies with NRF2 Blockade

BACKGROUND: Neomorphic IDH1 mutations disrupt the redox balance by promoting reactive oxygen species (ROS) production. However, the mechanism by which IDH1-mutant cells maintain ROS homeostasis remains elusive. It is also not known whether reprogrammed ROS homeostasis establishes targetable vulnerab...

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Bibliografiske detaljer
Udgivet i:J Natl Cancer Inst
Main Authors: Liu, Yang, Lu, Yanxin, Celiku, Orieta, Li, Aiguo, Wu, Qixin, Zhou, Yiqiang, Yang, Chunzhang
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792082/
https://ncbi.nlm.nih.gov/pubmed/30759236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djy230
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