CADD-09. TARGETING Nrf2 ANTIOXIDATIVE PATHWAY AS A NOVEL THERAPEUTIC STRATEGY FOR IDH1-MUTATED CANCERS

BACKGROUND: Mutations in isocitrate dehydrogenase (IDH1/2) are the most prevalent genetic abnormalities in lower grade glioma. Neomorphic enzyme activity of mutant IDH1/2 leads to the production of oncometabolite 2-hydroxyglutarate, accompanied with disruption of redox balance through aberrant NADP(...

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Detaylı Bibliyografya
Yayımlandı:Neuro Oncol
Asıl Yazarlar: Liu, Yang, Lu, Yanxin, Celiku, Orieta, Li, Aiguo, Yang, Chunzhang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2018
Konular:
Abstracts
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216774/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.1156
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