CADD-09. TARGETING Nrf2 ANTIOXIDATIVE PATHWAY AS A NOVEL THERAPEUTIC STRATEGY FOR IDH1-MUTATED CANCERS

BACKGROUND: Mutations in isocitrate dehydrogenase (IDH1/2) are the most prevalent genetic abnormalities in lower grade glioma. Neomorphic enzyme activity of mutant IDH1/2 leads to the production of oncometabolite 2-hydroxyglutarate, accompanied with disruption of redox balance through aberrant NADP(...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Liu, Yang, Lu, Yanxin, Celiku, Orieta, Li, Aiguo, Yang, Chunzhang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Abstracts
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216774/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.1156
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge