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CADD-09. TARGETING Nrf2 ANTIOXIDATIVE PATHWAY AS A NOVEL THERAPEUTIC STRATEGY FOR IDH1-MUTATED CANCERS
BACKGROUND: Mutations in isocitrate dehydrogenase (IDH1/2) are the most prevalent genetic abnormalities in lower grade glioma. Neomorphic enzyme activity of mutant IDH1/2 leads to the production of oncometabolite 2-hydroxyglutarate, accompanied with disruption of redox balance through aberrant NADP(...
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| Publicado no: | Neuro Oncol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6216774/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.1156 |
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