mTORC2/Rac1 Pathway Predisposes Cancer Aggressiveness in IDH1-Mutated Glioma

Isocitrate dehydrogenase (IDH) mutations are common genetic abnormalities in lower grade gliomas. The neomorphic enzyme activity of IDH mutants leads to tumor formation through epigenetic alteration, dysfunction of dioxygenases, and metabolic reprogramming. However, it remains elusive as to how IDH...

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Detaylı Bibliyografya
Yayımlandı:Cancers (Basel)
Asıl Yazarlar: Liu, Yang, Lu, Yanxin, Li, Aiguo, Celiku, Orieta, Han, Sue, Qian, Mingyu, Yang, Chunzhang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226122/
https://ncbi.nlm.nih.gov/pubmed/32224866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12040787
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