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mTORC2/Rac1 Pathway Predisposes Cancer Aggressiveness in IDH1-Mutated Glioma

Isocitrate dehydrogenase (IDH) mutations are common genetic abnormalities in lower grade gliomas. The neomorphic enzyme activity of IDH mutants leads to tumor formation through epigenetic alteration, dysfunction of dioxygenases, and metabolic reprogramming. However, it remains elusive as to how IDH...

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Bibliografiska uppgifter
I publikationen:Cancers (Basel)
Huvudupphovsmän: Liu, Yang, Lu, Yanxin, Li, Aiguo, Celiku, Orieta, Han, Sue, Qian, Mingyu, Yang, Chunzhang
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226122/
https://ncbi.nlm.nih.gov/pubmed/32224866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12040787
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