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Targeting IDH1-Mutated Malignancies with NRF2 Blockade
BACKGROUND: Neomorphic IDH1 mutations disrupt the redox balance by promoting reactive oxygen species (ROS) production. However, the mechanism by which IDH1-mutant cells maintain ROS homeostasis remains elusive. It is also not known whether reprogrammed ROS homeostasis establishes targetable vulnerab...
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| I publikationen: | J Natl Cancer Inst |
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| Huvudupphovsmän: | , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Oxford University Press
2019
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6792082/ https://ncbi.nlm.nih.gov/pubmed/30759236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djy230 |
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