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Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells

Caspases participate in regulated cell death mechanisms and are divided into apoptotic and proinflammatory caspases. The main problem in identifying the unique role of a particular caspase in the mechanisms of regulated cell death is their overlapping substrate specificity; caspases recognize and hy...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cell Death Differ
Hauptverfasser: Groborz, Katarzyna, Gonzalez Ramirez, Monica L., Snipas, Scott J., Salvesen, Guy S., Drąg, Marcin, Poręba, Marcin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205877/
https://ncbi.nlm.nih.gov/pubmed/31209360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0364-z
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