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Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells

Most caspases can be positioned unambiguously within the regulated cell death networks of apoptosis and pyroptosis, but the role of caspase-2, a highly conserved protease within the family, remains enigmatic. This is mainly due to lack of selective chemical and biochemical tools for the investigatio...

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Détails bibliographiques
Publié dans:Cell Death Differ
Auteurs principaux: Poreba, Marcin, Rut, Wioletta, Groborz, Katarzyna, Snipas, Scott J., Salvesen, Guy S., Drag, Marcin
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224280/
https://ncbi.nlm.nih.gov/pubmed/30976094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0329-2
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