Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1

Inflammatory cell death, or pyroptosis, is triggered by pathogenic infections or events. It is executed by caspase-1 (in the canonical pyroptosis pathway) or caspase-11 (noncanonical pathway), each via production of a cell-lytic domain from the pyroptosis effector protein gasdermin D through specifi...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Ramirez, Monica L. Gonzalez, Poreba, Marcin, Snipas, Scott J., Groborz, Katarzyna, Drag, Marcin, Salvesen, Guy S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Editors' Picks
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936834/
https://ncbi.nlm.nih.gov/pubmed/29414788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001329
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items