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Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1

Inflammatory cell death, or pyroptosis, is triggered by pathogenic infections or events. It is executed by caspase-1 (in the canonical pyroptosis pathway) or caspase-11 (noncanonical pathway), each via production of a cell-lytic domain from the pyroptosis effector protein gasdermin D through specifi...

詳細記述

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書誌詳細
出版年:J Biol Chem
主要な著者: Ramirez, Monica L. Gonzalez, Poreba, Marcin, Snipas, Scott J., Groborz, Katarzyna, Drag, Marcin, Salvesen, Guy S.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936834/
https://ncbi.nlm.nih.gov/pubmed/29414788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001329
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