Structurally Distinct α-Synuclein Fibrils Induce Robust Parkinsonian Pathology

OBJECTIVE: Alpha-synuclein (α-syn) is a major component of Lewy bodies, which are the pathological hallmark in Parkinson’s disease, and its genetic mutations cause familial forms of Parkinson’s disease. Patients with α-syn G51D mutation exhibit severe clinical symptoms. However, in vitro studies sho...

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Published in:Mov Disord
Main Authors: Hayakawa, Hideki, Nakatani, Rie, Ikenaka, Kensuke, Aguirre, Cesar, Choong, Chi-Jing, Tsuda, Hiroshi, Nagano, Seiichi, Koike, Masato, Ikeuchi, Takeshi, Hasegawa, Masato, Papa, Stella M., Nagai, Yoshitaka, Mochizuki, Hideki, Baba, Kousuke
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202333/
https://ncbi.nlm.nih.gov/pubmed/31643109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.27887
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