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Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid

α-Synuclein aggregates, a key hallmark of the pathogenesis of Parkinson’s disease, can be amplified by using their seeding activity, and the evaluation of the seeding activity of cerebrospinal fluid (CSF) is reportedly useful for diagnosis. However, conventional shaking-based assays are time-consumi...

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Τόπος έκδοσης:	Sci Rep
Κύριοι συγγραφείς:	Kakuda, Keita, Ikenaka, Kensuke, Araki, Katsuya, So, Masatomo, Aguirre, César, Kajiyama, Yuta, Konaka, Kuni, Noi, Kentaro, Baba, Kousuke, Tsuda, Hiroshi, Nagano, Seiichi, Ohmichi, Takuma, Nagai, Yoshitaka, Tokuda, Takahiko, El-Agnaf , Omar M. A., Ogi, Hirotsugu, Goto, Yuji, Mochizuki, Hideki
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Nature Publishing Group UK 2019
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6461702/ https://ncbi.nlm.nih.gov/pubmed/30979935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42399-0
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Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid

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