Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid

α-Synuclein aggregates, a key hallmark of the pathogenesis of Parkinson’s disease, can be amplified by using their seeding activity, and the evaluation of the seeding activity of cerebrospinal fluid (CSF) is reportedly useful for diagnosis. However, conventional shaking-based assays are time-consumi...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Kakuda, Keita, Ikenaka, Kensuke, Araki, Katsuya, So, Masatomo, Aguirre, César, Kajiyama, Yuta, Konaka, Kuni, Noi, Kentaro, Baba, Kousuke, Tsuda, Hiroshi, Nagano, Seiichi, Ohmichi, Takuma, Nagai, Yoshitaka, Tokuda, Takahiko, El-Agnaf , Omar M. A., Ogi, Hirotsugu, Goto, Yuji, Mochizuki, Hideki
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461702/
https://ncbi.nlm.nih.gov/pubmed/30979935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42399-0
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