Polyphosphates induce amyloid fibril formation of α-synuclein in concentration-dependent distinct manners

Polyphosphates (polyPs), chains of phosphate residues found in species across nature from bacteria to mammals, were recently reported to accelerate the amyloid fibril formation of many proteins. How polyPs facilitate this process, however, remains unknown. To gain insight into their mechanisms, we u...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Yamaguchi, Keiichi, So, Masatomo, Aguirre, César, Ikenaka, Kensuke, Mochizuki, Hideki, Kawata, Yasushi, Goto, Yuji
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8059054/
https://ncbi.nlm.nih.gov/pubmed/33676889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100510
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