Isoelectric point-amyloid formation of α-synuclein extends the generality of the solubility and supersaturation-limited mechanism

Proteins in either a native or denatured conformation often aggregate at an isoelectric point (pI), a phenomenon known as pI precipitation. However, only a few studies have addressed the role of pI precipitation in amyloid formation, the crystal-like aggregation of denatured proteins. We found that...

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Publicat a:Curr Res Struct Biol
Autors principals: Furukawa, Koki, Aguirre, Cesar, So, Masatomo, Sasahara, Kenji, Miyanoiri, Yohei, Sakurai, Kazumasa, Yamaguchi, Keiichi, Ikenaka, Kensuke, Mochizuki, Hideki, Kardos, Jozsef, Kawata, Yasushi, Goto, Yuji
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8244297/
https://ncbi.nlm.nih.gov/pubmed/34235468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.crstbi.2020.03.001
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