Heating during agitation of β(2)-microglobulin reveals that supersaturation breakdown is required for amyloid fibril formation at neutral pH

Amyloidosis-associated amyloid fibrils are formed by denatured proteins when supersaturation of denatured proteins is broken. β(2)-Microglobulin (β2m) forms amyloid fibrils and causes dialysis-related amyloidosis in patients receiving long-term hemodialysis. Although amyloid fibrils of β2m in patien...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Noji, Masahiro, Sasahara, Kenji, Yamaguchi, Keiichi, So, Masatomo, Sakurai, Kazumasa, Kardos, József, Naiki, Hironobu, Goto, Yuji
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2019
Pynciau:
Protein Structure and Folding
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816083/
https://ncbi.nlm.nih.gov/pubmed/31495783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009971
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