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Heparin‐induced amyloid fibrillation of β(2)‐microglobulin explained by solubility and a supersaturation‐dependent conformational phase diagram

Amyloid fibrils are fibrillar deposits of denatured proteins associated with amyloidosis and are formed by a nucleation and growth mechanism. We revisited an alternative and classical view of amyloid fibrillation: amyloid fibrils are crystal‐like precipitates of denatured proteins formed above solub...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: So, Masatomo, Hata, Yasuko, Naiki, Hironobu, Goto, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405432/
https://ncbi.nlm.nih.gov/pubmed/28249361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3149
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