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Supersaturation-limited and Unlimited Phase Transitions Compete to Produce the Pathway Complexity in Amyloid Fibrillation

Although amyloid fibrils and amorphous aggregates are two types of aggregates formed by denatured proteins, their relationship currently remains unclear. We used β(2)-microglobulin (β2m), a protein responsible for dialysis-related amyloidosis, to clarify the mechanism by which proteins form either a...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Adachi, Masayuki, So, Masatomo, Sakurai, Kazumasa, Kardos, József, Goto, Yuji
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2015
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505058/
https://ncbi.nlm.nih.gov/pubmed/26063798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.648139
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