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Supersaturation-limited and Unlimited Phase Transitions Compete to Produce the Pathway Complexity in Amyloid Fibrillation

Although amyloid fibrils and amorphous aggregates are two types of aggregates formed by denatured proteins, their relationship currently remains unclear. We used β(2)-microglobulin (β2m), a protein responsible for dialysis-related amyloidosis, to clarify the mechanism by which proteins form either a...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Adachi, Masayuki, So, Masatomo, Sakurai, Kazumasa, Kardos, József, Goto, Yuji
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505058/
https://ncbi.nlm.nih.gov/pubmed/26063798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.648139
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