Heparin-dependent aggregation of hen egg white lysozyme reveals two distinct mechanisms of amyloid fibrillation

Heparin, a biopolymer possessing high negative charge density, is known to accelerate amyloid fibrillation by various proteins. Using hen egg white lysozyme, we studied the effects of heparin on protein aggregation at low pH, raised temperature, and applied ultrasonic irradiation, conditions under w...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Nitani, Ayame, Muta, Hiroya, Adachi, Masayuki, So, Masatomo, Sasahara, Kenji, Sakurai, Kazumasa, Chatani, Eri, Naoe, Kazumitsu, Ogi, Hirotsugu, Hall, Damien, Goto, Yuji
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Protein Structure and Folding
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766966/
https://ncbi.nlm.nih.gov/pubmed/29101231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.813097
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