Heparin-dependent aggregation of hen egg white lysozyme reveals two distinct mechanisms of amyloid fibrillation

Heparin, a biopolymer possessing high negative charge density, is known to accelerate amyloid fibrillation by various proteins. Using hen egg white lysozyme, we studied the effects of heparin on protein aggregation at low pH, raised temperature, and applied ultrasonic irradiation, conditions under w...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Nitani, Ayame, Muta, Hiroya, Adachi, Masayuki, So, Masatomo, Sasahara, Kenji, Sakurai, Kazumasa, Chatani, Eri, Naoe, Kazumitsu, Ogi, Hirotsugu, Hall, Damien, Goto, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766966/
https://ncbi.nlm.nih.gov/pubmed/29101231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.813097
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