Breakdown of supersaturation barrier links protein folding to amyloid formation

The thermodynamic hypothesis of protein folding, known as the “Anfinsen’s dogma” states that the native structure of a protein represents a free energy minimum determined by the amino acid sequence. However, inconsistent with the Anfinsen’s dogma, globular proteins can misfold to form amyloid fibril...

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Foilsithe in:Commun Biol
Main Authors: Noji, Masahiro, Samejima, Tatsushi, Yamaguchi, Keiichi, So, Masatomo, Yuzu, Keisuke, Chatani, Eri, Akazawa-Ogawa, Yoko, Hagihara, Yoshihisa, Kawata, Yasushi, Ikenaka, Kensuke, Mochizuki, Hideki, Kardos, József, Otzen, Daniel E., Bellotti, Vittorio, Buchner, Johannes, Goto, Yuji
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2021
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7838177/
https://ncbi.nlm.nih.gov/pubmed/33500517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01641-6
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