Polyphosphates induce amyloid fibril formation of α-synuclein in concentration-dependent distinct manners

Polyphosphates (polyPs), chains of phosphate residues found in species across nature from bacteria to mammals, were recently reported to accelerate the amyloid fibril formation of many proteins. How polyPs facilitate this process, however, remains unknown. To gain insight into their mechanisms, we u...

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Gepubliceerd in:J Biol Chem
Hoofdauteurs: Yamaguchi, Keiichi, So, Masatomo, Aguirre, César, Ikenaka, Kensuke, Mochizuki, Hideki, Kawata, Yasushi, Goto, Yuji
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8059054/
https://ncbi.nlm.nih.gov/pubmed/33676889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100510
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