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Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid

α-Synuclein aggregates, a key hallmark of the pathogenesis of Parkinson’s disease, can be amplified by using their seeding activity, and the evaluation of the seeding activity of cerebrospinal fluid (CSF) is reportedly useful for diagnosis. However, conventional shaking-based assays are time-consumi...

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發表在:Sci Rep
Main Authors: Kakuda, Keita, Ikenaka, Kensuke, Araki, Katsuya, So, Masatomo, Aguirre, César, Kajiyama, Yuta, Konaka, Kuni, Noi, Kentaro, Baba, Kousuke, Tsuda, Hiroshi, Nagano, Seiichi, Ohmichi, Takuma, Nagai, Yoshitaka, Tokuda, Takahiko, El-Agnaf , Omar M. A., Ogi, Hirotsugu, Goto, Yuji, Mochizuki, Hideki
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461702/
https://ncbi.nlm.nih.gov/pubmed/30979935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42399-0
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