Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid

α-Synuclein aggregates, a key hallmark of the pathogenesis of Parkinson’s disease, can be amplified by using their seeding activity, and the evaluation of the seeding activity of cerebrospinal fluid (CSF) is reportedly useful for diagnosis. However, conventional shaking-based assays are time-consumi...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Kakuda, Keita, Ikenaka, Kensuke, Araki, Katsuya, So, Masatomo, Aguirre, César, Kajiyama, Yuta, Konaka, Kuni, Noi, Kentaro, Baba, Kousuke, Tsuda, Hiroshi, Nagano, Seiichi, Ohmichi, Takuma, Nagai, Yoshitaka, Tokuda, Takahiko, El-Agnaf , Omar M. A., Ogi, Hirotsugu, Goto, Yuji, Mochizuki, Hideki
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461702/
https://ncbi.nlm.nih.gov/pubmed/30979935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42399-0
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