E46K mutant α-synuclein is more degradation resistant and exhibits greater toxic effects than wild-type α-synuclein in Drosophila models of Parkinson's disease

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, which is characterized by progressive motor dysfunction as well as non-motor symptoms. Pathological and genetic studies have demonstrated that α-synuclein (αSyn) plays key roles in the pathogenesis of PD. Although several...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sakai, Ryusuke, Suzuki, Mari, Ueyama, Morio, Takeuchi, Toshihide, Minakawa, Eiko N., Hayakawa, Hideki, Baba, Kousuke, Mochizuki, Hideki, Nagai, Yoshitaka
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594597/
https://ncbi.nlm.nih.gov/pubmed/31242217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0218261
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