PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study

BACKGROUND: Cyclooxygenase-2 (COX-2), which is rapidly upregulated by inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory prostanoids. Successful positron emission tomography (PET) radioligand imaging of COX-2 in vivo could be a potentially powerf...

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Udgivet i:J Neuroinflammation
Main Authors: Shrestha, Stal, Kim, Min-Jeong, Eldridge, Mark, Lehmann, Michael L., Frankland, Michael, Liow, Jeih-San, Yu, Zu-Xi, Cortes-Salva, Michelle, Telu, Sanjay, Henter, Ioline D., Gallagher, Evan, Lee, Jae-Hoon, Fredericks, J. Megan, Poffenberger, Chelsie, Tye, George, Ruiz-Perdomo, Yanira, Anaya, Fernanda Juarez, Montero Santamaria, Jose A., Gladding, Robert L., Zoghbi, Sami S., Fujita, Masahiro, Katz, James D., Pike, Victor W., Innis, Robert B.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195739/
https://ncbi.nlm.nih.gov/pubmed/32359360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01804-6
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