First-in-human evaluation of [(11)C]PS13, a novel PET radioligand, to quantify cyclooxygenase-1 in the brain

PURPOSE: This study assessed whether the newly developed PET radioligand [(11)C]PS13, which has shown excellent in vivo selectivity in previous animal studies, could be used to quantify constitutive levels of cyclooxygenase-1 (COX-1) in healthy human brain. METHODS: Brain test-retest scans with conc...

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Publicat a:Eur J Nucl Med Mol Imaging
Autors principals: Kim, Min-Jeong, Lee, Jae-Hoon, Anaya, Fernanda Juarez, Hong, Jinsoo, Miller, William, Telu, Sanjay, Singh, Prachi, Cortes, Michelle Y., Henry, Katharine, Tye, George L., Frankland, Michael P., Montero Santamaria, Jose A., Liow, Jeih-San, Zoghbi, Sami S., Fujita, Masahiro, Pike, Victor W., Innis, Robert B.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8261645/
https://ncbi.nlm.nih.gov/pubmed/32399622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-020-04855-2
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