Improved glucose tolerance with DPPIV inhibition requires β‐cell SENP1 amplification of glucose‐stimulated insulin secretion

Pancreatic islet insulin secretion is amplified by both metabolic and receptor‐mediated signaling pathways. The incretin‐mimetic and DPPIV inhibitor anti‐diabetic drugs increase insulin secretion, but in humans this can be variable both in vitro and in vivo. We examined the correlation of GLP‐1 indu...

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Sparad:
Bibliografiska uppgifter
I publikationen:Physiol Rep
Huvudupphovsmän: Ferdaoussi, Mourad, Smith, Nancy, Lin, Haopeng, Bautista, Austin, Spigelman, Aliya F., Lyon, James, Dai, XiaoQing, Manning Fox, Jocelyn E., MacDonald, Patrick E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2020
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185381/
https://ncbi.nlm.nih.gov/pubmed/32339440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14420
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