Improved glucose tolerance with DPPIV inhibition requires β‐cell SENP1 amplification of glucose‐stimulated insulin secretion

Pancreatic islet insulin secretion is amplified by both metabolic and receptor‐mediated signaling pathways. The incretin‐mimetic and DPPIV inhibitor anti‐diabetic drugs increase insulin secretion, but in humans this can be variable both in vitro and in vivo. We examined the correlation of GLP‐1 indu...

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Dettagli Bibliografici
Pubblicato in:Physiol Rep
Autori principali: Ferdaoussi, Mourad, Smith, Nancy, Lin, Haopeng, Bautista, Austin, Spigelman, Aliya F., Lyon, James, Dai, XiaoQing, Manning Fox, Jocelyn E., MacDonald, Patrick E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185381/
https://ncbi.nlm.nih.gov/pubmed/32339440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14420
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