Structure—Activity Relationship of Antischistosomal Ozonide Carboxylic Acids

Semisynthetic artemisinins and other bioactive peroxides are best known for their powerful antimalarial activities, and they also show substantial activity against schistosomes—another hemoglobin-degrading pathogen. Building on this discovery, we now describe the initial structure—activity relations...

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Pubblicato in:J Med Chem
Autori principali: Wu, Jianbo, Wang, Xiaofang, Chiu, Francis C. K., Häberli, Ćecile, Shackleford, David M., Ryan, Eileen, Kamaraj, Sriraghavan, Bulbule, Vivek J., Wallick, Alexander I., Dong, Yuxiang, White, Karen L., Davis, Paul H., Charman, Susan A., Keiser, Jennifer, Vennerstrom, Jonathan L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7182039/
https://ncbi.nlm.nih.gov/pubmed/32134263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00069
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